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PMID: 22093723, DOI: 10.1016/j.jtcvs.2011.10.020
Individual responses vary based on baseline A1C, dose level, adherence, and lifestyle factors
This fundamental mechanistic difference has implications for metabolic effects, hepatic fat handling, and potentially which patient populations benefit most
This is largely due to rapid weight loss rather than direct toxicity
Aim for a minimum of eight to ten glasses of water daily, which translates to approximately two to 2.5 liters
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