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Assessment of consistency across finngen, PGC, UKB, and other GWAS datasets with meta-analysis To evaluate the consistency of our findings across multiple independent datasets, we conducted Mendelian randomization (MR) analyses using summary genetic data from the FinnGen consortium (R9) ( Psychiatric Genomics Consortium (PGC, and UK Biobank ( The number of individuals included in these analyses ranged from 133,164 to 306,119, as detailed in Supplementary Table S2
Application Analysis The type 2 diabetes mellitus segment had a tremendous growth rate, with a revenue share of 62.3% owing to the well-established role of GLP-1 receptor agonists in improving glycemic control, promoting weight loss, and offering cardiovascular benefits in patients with type 2 diabetes
Patients taking tirzepatide in both trials had a 1617% reduction in body weight, along with improvements in OSA-specific hypoxic burden, and high sensitivity C-reactive protein (a biomarker of systemic inflammation and cardiovascular risk) [113, 114]