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Pyke C, Heller RS, Kirk RK, rskov C, Reedtz-Runge S, Kaastrup P, et al

This is an important consideration for product formulation

Standard cagrilintide dosing follows a 12-week titration from 0.6mg to 2.4mg weekly (0.6mg weeks 1-4, 1.2mg weeks 5-8, 1.8mg weeks 9-12, 2.4mg week 13+)

There are also some limitations in this study, such as the relatively small number of patients and lack of samples of patients with a more advanced stage of NSCLC, such as stage IV, since ser/gly metabolism hyperactivation is associated to poor prognostic advanced NSCLC

Muscle-Liver substrate fluxes in exercising humans and potential effects on hepatic metabolism