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Although many enzymes in one-carbon metabolism are affected by the sex hormones testosterone and estradiol, the main reasons for sexual dimorphism in glutathione metabolism are the effects of estradiol and the GSH regulatory motif, which includes the inhibition of GS and GCL by GSH itself [Figure 2B]
Despite the detailed understanding of the physicochemical properties of NADs, the potential immunogenicity and toxicity of carriers and related modifications may pose additional challenges to safe and effective NADs delivery
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Whether NAD IV therapy is worth the cost depends on expectations and intent
Biol Psychiatry 75:307315
