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Researchers studying GLP-1R-specific signalling often use semaglutide as the reference single-agonist compound, with tirzepatide and retatrutide added to isolate the contribution of GIP and glucagon receptor activation in cell-based and animal models

Gotsis E, Anagnostis P, Mariolis A, Vlachou A, Katsiki N, Karagiannis A

Nature 455 (7210), 232236

Cytokines do not normally function as circulating endocrine molecules, and their presence in the periphery mostly represents spillover from their actual site of action

However, you will begin to feel the effects as soon as you take the first dose, as it will change your appetite and your eating habits