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Tesamorelin affects hepatic IGF-1 production and gluconeogenesis

However, these studies cannot definitely establish the absence of any risk because of methodological limitations, including small sample size and inconsistent comparator groups

Though often covered by insurance, newer GLP-1 medications are often much more expensive than other glucose-lowering medications like sulfonylureas, metformin, and thiazolidinediones

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Unlike immunosuppressive medications, GLP-1 receptor agonists primarily affect metabolic pathways rather than immune cell function or antibody production