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3 Roles and response mechanisms of heat shockrelated proteins in the pathogenesis of male infertility 3.1 Composition and functional basis of the HSF/HSP system in dynamic stress responses Under heat stress, the testicular cells activate a series of protective responses, among which heat shock factors (HSFs) and heat shock proteins (HSPs) play central roles (Widlak and Vydra, 2017)

It is found mainly in red meat, fish, and dairy products, in addition to being synthesized by the body

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This process helps prevent the accumulation of these reactive molecules, which can damage cellular structures