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Intramuscular injection has proven to be the most effective method for those with vitamin B12 deficiencies or choosing to boost their levels for other reasons, second only to intravenous which is most often administered under emergency situations

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A 2021 review in Frontiers in Pharmacology organised the wound-healing literature by tissue category, covering dermal, tendon, ligament, skeletal-muscle, osseous, peripheral-nerve, and vascular models (PMID 34267654)

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The peptide works through non-hormonal mechanisms, does not suppress natural production of any substance, and shows no rebound effects upon discontinuation