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For appropriately selected patients, they can produce meaningful weight loss, improve diabetes management, lower cardiovascular risk, and enhance overall metabolic health

Resistance training works by: Activating mTOR pathways: Mechanical tension from lifting triggers molecular pathways that promote muscle protein synthesis, counteracting the catabolic environment of caloric restriction Increasing insulin sensitivity: Muscle contractions enhance glucose uptake independent of insulin, improving metabolic health markers Stimulating anabolic hormones: Resistance exercise acutely increases growth hormone and testosterone, both protective against muscle loss Maintaining neuromuscular efficiency: Regular lifting preserves the brain-muscle connection, preventing the rapid strength losses seen with detraining The dose-response relationship is clear: 2 sessions weekly provides significant benefit, 3 sessions provide optimal results for most people, and 4+ sessions offer marginal additional gains for advanced trainees

Bioavailability was optimized

Khan MS, Fonarow GC, McGuire DK, et al

The route must be documented in the medical record before the claim goes out