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Besides, suppression of tumor growth was observed after miR-206 mimics transfection, which indicated downregulation of c-Met and cell cycle-related proteins in xenograft mouse models and in vitro (Zheng et al., 2015)

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Additionally, it downregulates SLC7A11 channel protein expression while upregulating ALOX3, further promoting ferroptosis (56)

60 ), FDR backbone 61 and FindMySequence 62

Discussion Across rodent and cell models, NNMT inhibition acts as a metabolic re-allocator, simultaneously relieving a methyl sink and diverting nicotinamide back to NAD salvage