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Another systematic review and Meta - analysis based on RCTs indicated that although curcumin can effectively improve IR in PCOS patients, its effectiveness in lipid regulation is still lacking (specifically, it has no significant impact on lipid parameters such as total cholesterol, LDL - C, HDL - C, and triglycerides) (Simental-Menda et al., 2022)

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Despite being on metformin and glimepiride, his diabetes control has worsened over the past year, with an HbA1c increasing from 7.5% to 8.6%

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