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In proof-of-concept studies, NNMT inhibitors (NNMTis) have demonstrated promise as potential treatments for obesity and obesity-related metabolic comorbidities (e.g., T2D, fatty liver) 8,9,13
Hormonal shifts: Declines in growth hormone, estrogen, or testosterone affecting metabolism
Use: Laboratory research only
When NNMT is highly active, it draws on SAM and can lower available NAD
(2013) Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans J Endocrinol Metab 3(12):715 AOD9604 vs Related GH-Axis Research Tools AOD9604s unique combination of GH receptor independence, direct lipolytic activity, absence of IGF-1 stimulation, and confirmed oral bioavailability makes it an irreplaceable research tool for studying adipose tissue metabolism and lipolysis without the systemic endocrine confounds associated with intact hGH or indirect GH secretagogues
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