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Additionally, the increase in microvascular blood flow in muscles contributes to reduced intramuscular fat accumulation and alleviation of myosteatosis, while AMPK pathway-mediated increased fat oxidation supports the mobilization of intramuscular fat, allowing for improvements in energy metabolism and reduction of fat within muscle tissue [39]

91 Evidence for the benefits of magnesium in bone health from supplementation studies is limited

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All patients received their previously established dose of metformin throughout the study

Generally, tirzepatide is well tolerated