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Excessive ROS can be detoxified by antioxidants (enzymes and non-enzymes) and in reactions catalyzed by superoxide dismutase (Cu-SOD, Zn-SOD, and Mn-SOD), GPX and catalase

Glutathione injections can decrease the risk for side effects like dark spots, free radicals, and infections

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Allow vials to reach room temperature before opening to reduce condensation uptake

In terms of safety, the main adverse event of RFA is esophageal stricture, with an incidence of approximately 5% reported in the meta-analysis and 11.8% reported in the SURF trial, but this can usually be resolved through endoscopic dilation