In humans, where C-cell GIP receptor expression appears to be lower, this effect may be minimal GIP and thyroid blood flow: Some preclinical data suggest GIP influences thyroid gland blood flow, which could theoretically affect hormone production and levothyroxine absorption in patients with remaining thyroid tissue No adverse thyroid effects in trials: In the SURMOUNT and SURPASS clinical trials, tirzepatide did not produce clinically significant changes in thyroid function tests in participants with normal thyroid function The presence of GIP receptors on thyroid tissue is an area of active research
BROAD, E.M., MAUGHAN, R.J
Patients with ALD have dysbiosis, represented by a reduction of the mean abundances of Bacteroidetes and an increase in Proteobacteria
The practical solution: switch to transdermal HRT The simplest way to avoid the absorption problem is to use non-oral hormone delivery
Researchers are already investigating GLP-1 receptor agonists for other conditions beyond OSA, including neurodegenerative diseases, anxiety, and cardiovascular health