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Thus, future studies are needed to better understand how PGC-1 promotes the mitochondrial biogenesis and how the proteasome affects the inner compartments of mitochondrial retrotranslocation to the OMM, and more practically, to test whether stabilization of K63-linked polyubiquitination is able to resist the oxidative stress induced impairment of mitochondrial function in animal models

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AAV- Ap2 -SIRT3 or AAV- Ap2 (5 10 10 vg/mice) were administered via direct injection in the tail vein in mice at the first and the sixth week of the experiment, to generate adipose tissue-specific SIRT3 overexpression (AT-SIRT3OE) and control (AT-NC) mice, respectively

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KLF11 mediates a critical mechanism in TGF-beta signaling that is inactivated by Erk-MAPK in pancreatic cancer cells

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