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In oncogene-induced senescence (OIS), fluctuations in NOTCH1 levels control this transition, switching from an early TGF--rich immunosuppressive secretome to a later inflammatory profile [19]
Patients were randomized in a 5:1:1 ratio to either WEGOVY 7.2 mg, WEGOVY 2.4 mg or placebo once weekly
The pro-autophagic effect of IGFBPs is also reflected in processes such as chemoresistance in hepatocellular carcinoma (59)
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