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Although severe TEAEs were infrequent overall, they increased with treatment intensity: 2% in the semaglutide group, 1.4% in the low-dose combination, 3.3% in the high-dose combination, and 10.1% in the triplet therapy arm
Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism
This dual mechanism distinguishes tirzepatide from single-action GLP-1 receptor agonists like semaglutide
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S.VoletiB
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