cagrilintide phase 3 What happens when you combine two peptide mechanisms? CagriSema — a co-administration of (amylin analog) + semaglutide — is showing additive metabolic effects in trials. Here's the science 👇 New Phase 3 data has

AOD 9604 safety data Six randomized, double-blind, placebo-controlled trials enrolling 925 adult subjects established AOD 9604 safety

And while the MTHFR variants primarily impact folate metabolism, the interconnectedness of the methylation cycle means that it indirectly affects vitamin B12 utilization as well

Day 46 peak (Figure S4C) approximately 1.52 higher than the 8-day average

The authors concluded that due to the high prevalence of MTHFR variants and how crucial it is to assure pregnant women get adequate supplementation, L-methylfolate may be the best option to avoid blood folate deficiencies. The study also notes that excessive ingestion of folic acid could mask an undiagnosed B12 deficiency, and that it was unlikely that methylfolate would mask a B12 deficiency in the same way

What we know about this peptide comes primarily from animal studies and anecdotal accounts