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The reduction in renal blood flow can cause permanent damage to already compromised kidneys
Due to their various modes of action, which include vasodilation, natriuresis, glucose and weight control, and direct cardioprotective effects, GLP-1 receptor agonists have therapeutic potential for treatment of heart failure (41)
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Preclinical studies document stimulation of collagen and glycosaminoglycan synthesis, upregulation of antioxidant enzymes including superoxide dismutase, and activation of matrix metalloproteinase pathways involved in tissue remodeling and scar resolution
Common side effects include: Nausea (most common, usually improves over time) Vomiting or diarrhea Constipation Rarely, pancreatitis or gallbladder issues For a deeper dive into risks and what to watch for, see our dedicated guide: GLP-1 Side Effects Explained by Doctors
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