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Brain Res 995 , 151157 (2004)
Key research applications include oxidative stress reduction and cellular protection, liver detoxification and heavy metal elimination, immune function support through white blood cell activity, skin tone and pigmentation research via melanin synthesis modulation, and anti-inflammatory pathways
After years of research, it has now been shown that a deficiency of the vitamin leads to an increase in myelin-damaging cytokines and a decrease in myelin-promoting cytokines (34)
This is why the distinction between broadly activating the pathway and specifically disrupting an inhibitory interaction matters: removing a specific negative regulator that is overexpressed in a particular tissue is mechanistically different from constitutively switching the pathway on
& Nusse, R
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