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The guiding principle is to find the lowest effective dose that comfortably sustains continued outcomes for the long term, rather than rushing everyone to the maximum dose in the minimum time
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Data from small studies suggest preconception GLP-1 use may help improve pregnancy odds in this patient population
In UK practice, NICE guidance recognises these benefits, though SGLT2 inhibitors are typically prioritised for cardiorenal protection, with GLP-1 receptor agonists with proven cardiovascular benefit considered when SGLT2 inhibitors are unsuitable
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