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After the success of peptide agonists of GLP-1R (a class B G-protein coupled receptor) in the treatment of diabetes, drug discovery scientists saw the opportunity for small molecule agonists of GLP-1R

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Overexpression of COX2 is reported in many types of cancer, including cutaneous melanoma, which contributes to tumor progression and angiogenesis (225)

Application in Studies of Glucose Metabolism Disorders and Diabetes Glucose metabolism disorder is a hallmark of diabetes, insulin resistance, and related metabolic diseases