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During significant caloric restriction, the body may reduce its metabolic rate as a protective mechanism, which can manifest as decreased energy

PMC 1895957

Common gastrointestinal side effects occur in the majority of patients and include nausea (reported in 20-50% depending on the agent and dose), vomiting, diarrhea, constipation, and abdominal pain

Recurrent pancreatitis episodes have been reported in some patients despite dose reduction or medication changes, suggesting individual susceptibility factors that standard screening may not identify

Serum dehydroepiandrosterone levels are associated with lower risk of type 2 diabetes: the Rotterdam Study