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41 Studies have found that individuals with lower CYP1A2 activity have increased reports of symptoms of toxicity, as caffeine is hepatically metabolized by CYP1A2 which causes caffeine to be absorbed more slowly
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Cifone MG, Alesse E, Di Marzio L, et al
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Individuals with type 2 diabetes were excluded from this particular trial, meaning the results reflect outcomes in adults with obesity or overweight but without diabetes
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