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The mechanism may involve changes in blood composition or in vessel walls that promote clotting under certain conditions and may increase clotting
Split doses over 1.5 mL
8-OHdG ( )
Phase II Jastreboff 2023 NEJM: -24.2% at 12mg/48w for retatrutide vs SURMOUNT-1 Jastreboff 2022: -20.9% at 15mg/72w for tirzepatide
Meanwhile, treatment options may include medications to reduce blood pressure in the portal vein, endoscopic procedures to stop bleeding, or in severe cases, surgical intervention
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