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Abstract Purpose of Review This review will summarize the most contemporary trials for glucagon-like peptide 1 receptor agonists (GLP1-RA) and sodium-glucose cotransporter 2 inhibitors (SGLT2-i) and present guidance on management and recommendations on adjunctive tapering of insulin in patients with insulin-dependent diabetes mellitus, which we term de-insulinization. Recent Findings GLP1-RA and SGLT2-i are the principal classes of diabetes medications evidencing cardiovascular benefit

Global assessment of the evidence The Modified Bradford Hill Criteria was used to assess the potential relationships among various available evidence [33,34,35]

Parallelly, ESAM and CAR trigger intercellular adhesion and modulate endothelial permeability during inflammation [38]

Landmark trialsLEADER (13% MACE), SUSTAIN-6 (26%), and SELECT (20%)demonstrate major reductions in heart attack, stroke, and cardiovascular death