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[11] KPV , as proposed by Bhm et al., [1] may carry much of the anti-inflammatory potential attributed to the larger alpha-MSH molecule in laboratory models, potentially through reduction of NF-B and MAP kinase signaling and interactions with nitric oxide pathways

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10.1016/J.JNUTBIO.2005.05.002 79 YeL.XuY.WangL.ZhangC.HuP.TongS.et al (2021)

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The cyclical dosing structure researchers use escalating within a defined window, followed by a rest period reflects an understanding of the peptide as a signaling molecule rather than a substance that accumulates and produces dose-dependent effects the way a drug typically does