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Autoimmune Progesterone Dermatitis (APD) also known as progestogen hypersensitivity is a rare immune-mediated reaction in which the body mounts an allergic or autoimmune response to endogenous progesterone or synthetic progestins, leading to cyclical skin and systemic symptoms that worsen during the luteal phase of the menstrual cycle

Laboratory studies show modulation of genes involved in cell proliferation, immune response, and stress resistance

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