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251,252 In the canonical cascade, ligand binding (e.g., Jagged1/2, DLL1/3/4) to Notch receptors (Notch14) induces a two-step proteolytic cleavage, culminating in the release of the Notch intracellular domain (NICD), a cleaved cytoplasmic signaling domain that mediates intracellular signal transduction, by -secretase
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Dysregulation of these factors in the eye can lead to corneal melting and scarring with deleterious consequences
Operational changes are not easily or quickly implemented, but GLP-1 usage is not going away, and only shows signs of growing
