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Li exposure down-regulates ER levels to suppress ER -mediated METTL1 and MBOAT1 transcription, and also suppresses METTL1 -mediated m7G modification on MBOAT1 mRNA to reduce MBOAT1 mRNA stability
Trends Endocrinol Metab (2019) 30(9):57889
Clinical studies reveal that patients can lose 12-15% of their body weight within six weeks when combining medication with proper lifestyle modifications
By acting on receptors in the brain, these medications help reduce hunger, increase feelings of fullness, and ultimately support weight loss
Trial Phase 1b (Lau et al., 2021) Phase 1b Duration 20 weeks Population (N) Multiple-ascending-dose study Key Result Cagrilintide half-life ~159195 hours
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