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5 Conclusions The use of SGLT-2 inhibitors and GLP-1 RAs in patients with cardiovascular risk has been well-established over the past decade

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A 2024 Reuters analysis by Prime Therapeutics (a large PBM) reported that in the first two years after introduction, patients on weight-loss GLP-1s actually had higher total annual healthcare costs than matched controls (driven by drug costs and some medical utilization) ( [42] )

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Tirzepatide may be the better choice when Availability is the most obvious advantage

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Increased activation of the CeA output neurons seems to be associated with increased fear-related behavior (Mohler, 2012)

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