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doi:10.1001/archfaci.8.4.252 Leyden J, Stephens TJ, Finkey MB, Barkovic S
Thiamine deficiency and neurological symptoms in patients with hematological cancer receiving chemotherapy: a retrospective analysis
GHK-Cu works through copper delivery to metalloenzymes and broad gene expression modulation, affecting not only collagen synthesis but also collagen cross-linking (via lysyl oxidase), glycosaminoglycan production, anti-inflammatory pathways, and antioxidant defense systems
Further accumulation of uremic toxins, which leads to uremic syndrome, can, among others, cause neurotoxicity, disruption in the BBB integrity, oxidative stress, neuroinflammation, and disturbance of brain neurotransmitter amino acids balance (Hamed, 2019)
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