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Reported concerns may include headache, nausea, injection-site irritation, fatigue, or unpredictable responses depending on product quality and route of administration
Surprisingly, tri-agonist treatment lowered plasma insulin levels to a greater extent than the GLP-1R/GIP coagonist, which may indicate greater insulin sensitivity
Results showed that GLP-1 receptor agonists and SGLT2 inhibitors were superior in reducing the risk of MACE when compared to DPP-4 inhibitors (HR 086 [082089] and 086 [082090], respectively), but no difference was found between SGLT2 inhibitors and GLP-1 receptor agonists in reducing rate of MACE (HR of 101 (094107)) (68)
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