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The evoke randomised, double-blind, placebo-controlled studies represent some of the largest trials to date investigating a GLP-1 RA in AD, enrolling a combined total of 3,808 adults aged 5585 years with mild cognitive impairment (MCI) or mild dementia due to AD confirmed by amyloid biomarkers
Pemvidutide Pemvidutide, another weekly GLP-1/glucagon dual agonist, is under evaluation in the ongoing phase 2 IMPACT trial (NCT05989711) in 190 individuals with histologically confirmed MASH and fibrosis stages F2-F3 [47]
The SUSTAIN 10 trial demonstrated a 1.7% reduction at week 30
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