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Doses are adjusted slowly and thoughtfully, only in small increments and only when theres a clear reason to do so, says Class

Stroke 42(6):17811786

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Adherence to the prescribed titration schedule is essential for minimizing gastrointestinal side effects and achieving long-term metabolic goals

Renal reabsorption can also be low in certain health states such as pregnancy, having excess body fat, and chronic fatigue syndrome