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In isolated cardiomyocytes, GLP-1 receptor agonists activated PI3K/Akt, AMPK, and cAMP/PKA pathways while reducing NOX4-mediated oxidative stress, signalling cardioprotective effects by alleviating ER stress-induced apoptosis [51]

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Those with co-occurring obesity or type 2 diabetes may be eligible for GLP-1 agonist therapy for these licensed indications, and any observed effects on alcohol consumption could be monitored and reported as part of ongoing research efforts

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