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This triple-action mechanism distinguishes it from existing agents such as semaglutide (a GLP-1 receptor agonist) and tirzepatide (a dual GLP-1/GIP receptor agonist), and may offer enhanced effects on weight reduction and metabolic regulation, though the full clinical profile is still being established

J Clin Endocrinol Metab 95:879886 Nauck MA, Siemsgl J, rskov C, Holst JJ (1996) Release of glucagon-like peptide 1 (GLP-1 [7-36 amide]), gastric inhibitory polypeptide (GIP) and insulin in response to oral glucose after upper and lower intestinal resections

Genes such as FTO , GLP1R , MC4R , and TCF7L2 shape baseline appetite and glucose handling, and the PlexusDx Precision Peptide Genetic Test reads 14 pathways, 49 peptides, 150+ genetic insights across them

Potential for Synergy: The hope is that the effects of combining tesamorelin and retatrutide might be synergistic, meaning the combined effect is greater than the sum of their individual parts

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