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Mayo Clinics ENDO 2025 study of 120 postmenopausal women found tirzepatide plus HRT produced 17% weight loss vs 14% alone over 18 months, with 45% of HRT users hitting 20%+ loss vs 18% of non-users (see our tirzepatide vs semaglutide analysis)
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The most frequently reported adverse effects are gastrointestinal in nature, including nausea, vomiting, diarrhoea, constipation, and abdominal discomfort
Rest in a cool environment and monitor your blood glucose if you have a monitor available, especially if you also take insulin or other diabetes medications
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