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DPP-4 is highly expressed within enterocytes, the major absorptive epithelial cell type, and genetic elimination of Dpp4 expression within cells targeted by Vil1 -Cre reduces intestinal DPP-4 activity by up to approximately 90% (20)

Nausea and vomiting are frequent when starting, and diarrhea, abdominal pain, or constipation can occur as your system adjusts

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These symptoms could indicate that the combination is stressing your GI tract

Data from clinical studies In an observational study involving 20 diabetic subjects receiving background metformin therapy, exenatide treatment over 16 weeks resulted in improved flow-mediated vasodilation of the brachial artery following 5 min of forearm ischemia, as assessed by ultrasound echocardiography, compared to patients treated with glimepiride [85]