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Nonalcoholic fatty liver disease (NAFLD) is a global health issue, affecting nearly a 32 percent of adults 40 percent of men and 26 percent of women, according to the National Institutes of Health (NIH)
The microglial branch KYN 3-monooxygenase (KMO) metabolizes KYN into 3-hydroxykynurenine (3-HK), which can then follow two main metabolic routes: conversion into 3-hydroxyanthranilic acid (3-HAA) via kynureninase or transformation into xanthurenic acid through KAT
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& Lewis, K
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