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When mice were found to be deficient in CXCR4, there was a significant reduction in pre-B cells in their BM and an increase of pre-B cells in the blood [11], This suggests that CXCR4 contributes to the retention of pre-B cells in the BM, preventing them from moving into the bloodstream

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This suggests that while mood changes can occur, they may not be substantially different from what happens in untreated populations or with placebo

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