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The incretin hormone GIP is upregulated in patients with atherosclerosis and stabilizes plaques in ApoE(-/-) mice by blocking monocyte/macrophage activation
Clinically, several GLP-1 RAs are approved or under study for obesity
doi: 10.1074/jbc.270.45.26762 64 NicholKACouzensMHShineJHerzogHCunninghamAM
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Future studies are needed to identify which people with MS are most likely to benefit from taking a GLP-1, the safest dosing strategies, and whether these medications have long-term disease-modifying effects in MS, she says
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