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Age : Proteolytic enzyme activity and organ function change with age, altering clearance

MECHANISM CATEGORIES SAFETY Side effects Generally well-tolerated in trials at the doses tested Injection-site reactions Known interactions Not characterized in Phase 3 Contraindications Pregnancy/lactation (unstudied) REGULATORY STATUS FDA Not FDA-approved as a drug

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Tab 1: Top 50 proteins in TCR-T coculture versus monoculture