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267 GAS6, secreted by stromal cells such as CAFs and macrophages, binds to AXL, promoting its dimerization, autophosphorylation, and activation of downstream survival pathways, including the PI3K/AKT, MAPK/ERK, and NF-B pathways
[3] Fulghesu AM, Ciampelli M, Muzj G, et al
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43,44 Given these neutral-to-concerning results, there is currently no evidence to support initiating GLP-1RAs for the primary treatment of HFrEF
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