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Increased lipase and alanine aminotransferase were noted in 3 (23.1%) and 1 (7.7%) of the patients, respectively, with none of those resulting in pancreatitis and/or cholelithiasis
191,192 In vascular endothelial cells, GLP-1R activation stimulates endothelial nitric oxide synthase (eNOS), promoting nitric oxide (NO) production and improving endothelium-dependent vasodilation
Lancet 386, 147283 (2015)
High Blood Press Cardiovasc Prev 24:107114 Tanaka A, Shimabukuro M, Okada Y, Sugimoto K, Kurozumi A, Torimoto K, Hirai H, Node K (2020) PROCEED trial investigators
Reduced vagal tone in these conditions exacerbates metabolic dysregulation, prompting researchers to investigate novel non-pharmacologic strategies targeting the vagus nerve
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