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5 Examples of GLP-1 receptor agonist injections include liraglutide (Saxenda), semaglutide (Ozempic for diabetes, Wegovy for obesity), and dulaglutide (Trulicity, primarily for diabetes but with potential off-label use for obesity)
The highest TM scores for predicted models of engineered fusion proteins were 0.928, 0.946, and 0.930 for nGLP1-DARPin, mGLP1-DARPin-1, and mGLP1-DARPin-2, respectively
The protein concentrations were quantified using a bicinchoninic acid (BCA) reagent according to the manufacturers instructions
While the FDA label historically suggested short-term use of up to 12 weeks, clinical evidence supports longer-term use under physician supervision for appropriate patients
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