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Tirzepatide (brand names Mounjaro and Zepbound) is a once-weekly injectable medication that activates two hormone pathways simultaneously, producing greater weight loss than any previously approved medication in clinical trials
Discontinuation rates due to adverse events (12.2% and 18.2% vs 4.0% with placebo) were highly correlated with baseline BMI and included discontinuations for perceived excessive weight loss
After an IV course, if continued therapy is needed, patients are often switched to oral ALA supplements (since oral forms are readily available for maintenance therapy)
If sleep is a priority, adding 275mg bisglycinate at bedtime fills the gap different form, different purpose
This is a general pharmacokinetic principle based on the protein stability characteristics of each formulation
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