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This confirms one earlier uncontrolled study of low-dose naltrexones efficacy for Crohns disease (Smith 2007)

The headline results at 80 weeks were: 12 mg dose: average weight loss of 28.3% (approximately 70.3 lbs / 31.9 kg) 9 mg dose: average weight loss of 25.9% (approximately 64.4 lbs / 29.2 kg) 4 mg dose: average weight loss of 19.0% (approximately 47.2 lbs / 21.4 kg) Placebo: average weight loss of just 2.2% Perhaps most striking was the proportion of patients hitting bariatric-surgery-level outcomes: at the highest dose, 45.3% of participants lost 30% or more of their body weight , and 65.3% reduced their BMI to below 30 kg/m meaning they were no longer classified as living with obesity by the end of the trial

pmid:18306930 11

The shift from surface treatments to cellular ones reflects a better understanding of why skin ages

Compare injectable vs oral peptide delivery to understand the bioavailability differences