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Exenatide (twice-daily) and lixisenatide are GLP-1 receptor agonists based on exendin-4 that overcome cleavage by DPP-4, however, their half remains short with ~ 24 h due to renal elimination

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Hydration and Timing Strategies for Faster Relief Drink 2.53 liters of water daily, distributed throughout the day in 250350 mL intervals

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As with most diabetes treatments, individual responses vary, and improvements depend on adherence to the prescribed dose, diet, and exercise